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The studies are consistent with the hypothesis that SAMe administered orally is bioavailable in an active form or as an active metabolite in the brain

2019, IntechOpen: Rijeka Fischer PM, Zheleva DI (2002) Liquid-phase peptide synthesis on polyethylene glycol (PEG) supports using strategies based on the 9-fluorenylmethoxycarbonyl amino protecting group: application of PEGylated peptides in biochemical assays

It converts uridine into pseudouridine in both mitochondria and cytosol, thus the clinical findings of both a mitochondrial myopathy and an autosomal recessive disorder

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doi: 10.1016/j.expneurol.2013.05.011 62 ArgellesJ